• Abstract

Corticotropin-releasing factor (CRF) orchestrates our body's response to stressful stimuli. Pain is often stressful and counterbalanced by activation of CRF receptors along the nociceptive pathway, although the involvement of the CRF receptor subtypes 1 and/or 2 (CRF-R1 and CRF-R2, respectively) in CRF-induced analgesia remains controversial. Thus, the aim of the present study was to examine CRF-R1 and CRF-R2 expression within the spinal cord of rats with Freund's complete adjuvant-induced unilateral inflammation of the hind paw using reverse transcriptase polymerase chain reaction, Western blot, radioligand binding, and immunofluorescence confocal analysis. Moreover, the antinociceptive effects of intrathecal (i.t.) CRF were measured by paw pressure algesiometer and their possible antagonism by selective antagonists for CRF-R1 and/or CRF-R2 as well as for opioid receptors. Our results demonstrated a preference for the expression of CRF-R2 over CRF-R1 mRNA, protein, binding sites and immunoreactivity in the dorsal horn of the rat spinal cord. Consistently, CRF as well as CRF-R2 agonists elicited potent dose-dependent antinociceptive effects which were antagonized by the i.t. CRF-R2 selective antagonist K41498, but not by the CRF-R1 selective antagonist NBI35965. In addition, i.t. applied opioid antagonist naloxone dose-dependently abolished the i.t. CRF- as well as CRF-R2 agonist-elicited inhibition of somatic pain. Importantly, double immunofluorescence confocal microscopy of the spinal dorsal horn showed CRF-R2 on enkephalin (ENK)-containing inhibitory interneurons in close opposition of incoming mu-opioid receptor-immunoreactive nociceptive neurons. CRF-R2 was, however, not seen on pre- or on postsynaptic sensory neurons of the spinal cord. Taken together, these findings suggest that i.t. CRF or CRF-R2 agonists inhibit somatic inflammatory pain predominantly through CRF-R2 receptors located on spinal enkephalinergic inhibitory interneurons which finally results in endogenous opioid-mediated pain inhibition.

•olive oil cake as the basic nutrient source showed that it could be a good substrate for lipase and protease production in SSF by yeasts Candida rugosa, providing necessary nutrients and physical support for the yeast growth and enzyme production.

•Lipase and protease production could be further improved by careful selection and addition of various carbon and nitrogen sources.

•The fermentation of the olive cake by non-toxic food approved strain may improve the substrate value as animal feed.

Phase I intervention in a skeletal

Class III case can involve

maxillary traction with a facemask,

often combined with rapid

maxillary expansion, followed by

orthodontic correction using Class

III mechanics.1 After cessation of

growth, however, treatment options

may be limited to surgical orthodontic

therapy.2,3 Although surgical treatment might produce

the best results, many patients reject

this option due to apprehension,

cost, or esthetic concerns.4-6

Orthodontic camouflage treatment

is possible in borderline cases, but

it is difficult to decompensate the

dentition and correct the occlusion

without jeopardizing the dentalperiodontal

equilibrium.

ABSTRACT

The goal of this study was to investigate the occurrence and distribution of hyperdontia, hypodontia (which

includes mesiodens and fused teeth), talon cusps, microdontia (which includes peg-shaped lateral incisors), and

macrodontia in patients attending private dental clinics in Gharyan, Libya. During ordinary patient

examinations, the inquiry was undertaken clinically and radiographically. A total of 1219 participants were

included in the study (358 males and 861 females). 57 of patients had dental anomalies in the percentage of

(4.67%), 21 patients (1.72%) had missing teeth, 15 of them had one missing permanent tooth and 6 patients had

two missing permanent teeth (the lower 2nd premolar was the most tooth loss 0.49%). In addition, the study

showed that 16 patients had supernumerary teeth, 10 patients had microdontia and 7 patients had macrodontia,

whereas, two patients had talon cusp. Early detection of a treatable abnormality is critical in developing a

thorough treatment strategy for the patient. Some of the unpleasant impact should be avoidable. In some

circumstances; functional, cosmetic, and occlusal discord can be detected early enough to warrant interpret of

sessional consultation and treatment.

KEYWORDS: dental anomalies; hypodontia; microdontia; macrodontia

Abstract

The rock units of Wadi El-shati were classified to group of clusters to explain the concentration of iron ore by using enhanced satellite image. The several images of single band of Thematic Mapper (TM7) of Landsat were combined to produce multispectral image bands. It was processed by group of filters after the false color image has been made. The filtered image was classified with unsupervised classification after the image ratio has been done by dividing band 3 on band1. Finally, we reached the classified image has concentration of iron tone.

Single carrier with frequency domain equalization (SC/FDE) substantially out performs OFDM in BER performance for Ultra Wideband (UWB), a result already reported. In this paper we provide an explanation and justify this superiority. We showed besides, by only a proper selection of both cyclic prefix duration and the period of fast Fourier transform an extra gain is obtainable. This performance enhancement is in favor of SC/FDE's superiority for UWB in the context of internet of things.