This paper demonstrates a new approach in solving problems with capacity issues within a cement factory in Libya using the Witness simulation package that enables the development of discrete and continuous simulation model to simulate these processes. The model aims to support the implementation of management systems in Supply Chain Management and the introduction of Just-In-Time systems. In order to carry out the above, research has been carried out into processes of SCM and J.I.T. The developed Simulation model is based on Libyan Cement industry, exploring supply chain management (SCM) and Just IN Time (JIT) system from start to end of the processes. Therefore, the aim and objective of investigating supply chain management and applying JIT to the cement factory using simulation at the very stage has been successful and has exercised with the simulation scenarios 1,2 and 3. This was achievable simply based on many assumptions as addressed above and with the help of the witness software that executes duties with the aid of input and output rules that need to be applied accordingly.

This work considers a harvested logistic population for which birth rate, carrying capacity and harvesting rate all vary slowly with time. Asymptotic results from earlier work, obtained using a multiscaling technique, are combined to construct approximate expressions for the evolving population for the situation where the population initially survives to a slowly varying limiting state, but then, due to increasing harvesting, is reduced to extinction in finite time. These results are shown to give very good agreement with those obtained from numerical computation.

In the present paper, the coefficient estimate of a class of funtions starlike with respect to k-symmetric points defined by generalised derivative operator will be studied. The integral representation and several coefficient inequalities of functions belonging to this class will be given.

One of the most promising new targets for trypanocidal drugs to emerge in recent years is the cyclic AMP (cAMP) phosphodiesterase (PDE) activity encoded by TbrPDEB1 and TbrPDEB2. These genes were genetically confirmed as essential, and a highaffinity inhibitor, CpdA, displays potent antitrypanosomal activity. To identify effectors of the elevated cAMP levels resulting from CpdA action and, consequently, potential sites for adaptations giving resistance to PDE inhibitors, resistance to the drug was induced. Selection of mutagenized trypanosomes resulted in resistance to CpdA as well as cross-resistance to membranepermeable cAMP analogues but not to currently used trypanocidal drugs. Resistance was not due to changes in cAMP levels or in PDEB genes. A second approach, a genome-wide RNA interference (RNAi) library screen, returned four genes giving resistance to CpdA upon knockdown. Validation by independent RNAi strategies confirmed resistance to CpdA and suggested a role for the identified cAMP Response Proteins (CARPs) in cAMP action. CARP1 is unique to kinetoplastid parasites and has predicted cyclic nucleotide binding-like domains, and RNAi repression resulted in >100-fold resistance. CARP2 and CARP4 are hypothetical conserved proteins associated with the eukaryotic flagellar proteome or with flagellar function, with an orthologue of CARP4 implicated in human disease. CARP3 is a hypothetical protein, unique to Trypanosoma. CARP1 to CARP4 likely represent components of a novel cAMP signaling pathway in the parasite. As cAMP metabolism is validated as a drug target in Trypanosoma brucei, cAMP effectors highly divergent from the mammalian host, such as CARP1, lend themselves to further pharmacological development

In the present paper, two new subclasses of analytic functions with respect to k-symmetric points defined by differential operator. Some interesting properties belonging to these classes are provided.

Luotonins and its derivatives (Isoluotonins) are alkaloids from the aerial parts of Peganum nigellastrum Bunge. that display three major skeleton types. Luotonins A, B, and E are pyrroloquinazolinoquinoline alkaloids,. A few methods were known for the sysnthesis of Isoluotonin All luotonins have shown promising cytotoxicities towards selected human cancer cell lines, especially against leukemia P-388 cells. Luotonin A is the most active one, with its activity stemming from topoisomerase I-dependent DNAcleavage. Such intriguing biological activities and unique structures have led not only to the development of synthetic methods for the efficient synthesis of these compounds, but also to interest in structural modifications for improving the biological properties. Recent progress in the study of luotonins is covered. 

Toyota, in Japan started the creation of this method in the early 1960's and hence it is also known as the “Toyota Production System” as it was used for their production of their automobiles. Therefore, the best definition of this system comes from Toyota i.e. JIT is a disciplined programme for improving overall productivity and reducing waste. It provides for the cost-effective production and delivery of only the necessary required parts, in the right quantity, at the right time and place, while using a minimum amount of facilities, equipment, materials and human resources. JIT is dependent upon the balance between the supplier's flexibility and user's stability. It is accomplished through the application of specific techniques that require total employee involvement and teamwork.